|
KMID : 0880220200580080633
|
|
Journal of Microbiology
2020 Volume.58 No. 8 p.633 ~ p.647
|
|
|
Recent advances in the development of β-lactamase inhibitors
|
|
Jalde Shivakumar S.
Choi Hyun-Kyung
|
|
|
Abstract
|
|
|
|
β-Lactam antibiotics are the most commonly prescribed antibiotics worldwide; however, antimicrobial resistance (AMR) is a global challenge. The β-lactam resistance in Gram-negative bacteria is due to the production of β-lactamases, including extended-spectrum β-lactamases, metallo-β-lactamases, and carbapenem-hydrolyzing class D β-lactamases. To restore the efficacy of BLAs, the most successful strategy is to use them in combination with β-lactamase inhibitors (BLI). Here we review the medically relevant β-lactamase families and penicillins, diazabicyclooctanes, boronic acids, and novel chemical scaffold-based BLIs, in particular approved and under clinical development.
|
|
|
KEYWORD
|
|
|
β-lactamase inhibitors, anti microbial resistance (AMR), serine-β-lactamase, metallo-β-lactamases (MBL), diazabicyclooctanes (DBO), boronic acids
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|